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Vitamin B-6 (as pyridoxine HCl): In studies cited on the Physician’s Desk Reference Online, Vitamin B-6 pyridoxine HCl has been shown to lower blood pressure and total cholesterol levels and increase HDL-cholesterol levels. B-6 is also a part of numerous biochemical reactions, such as amino acid and sugar metabolism, nucleic acid synthesis, and more. "I'm concerned about the lack of safety data, I'm concerned about the fact that this drug has only been tested for six months and only tested in women who were also taking estrogen therapy, and I'm outraged that the studies on Intrinsa thus far have all been sponsored by the manufacturer and that not one of those studies was ever submitted for publication to a peer review medical journal," says NYU endocrinologist Loren Wissner Greene, MD.
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